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This policy reflects advice from professional bodies, such as the American College of Occupational and Environmental Medicine (ACOEM), which notes that the present availability of coverage for obesity care is piecemeal and calls for guidance on how to operationalize evidence-based behavioral, nutritional, pharmacological, and surgical obesity treatment modalities as health benefits. The ACOEM further notes that obesity represents an ongoing cost to employers and society at large in the form of current and future health care expenses, absenteeism, presenteeism, and workers compensation costs related to injuries and illnesses. OPMs 2025 Call Letter, issued January 15, 2025, identified this context of rising utilization and cost amidst inconsistent application of comprehensive, evidence-based care

This distinguishes pan-ERR activation from anorexigenic or stimulant mechanisms and emphasizes direct metabolic reprograming

Diet and exercise routines that once worked may no longer be as effective

April 2026 [2] Fabi S, et al